Disposable Pipette Extraction (DPX) Coupled to HPLC-DAD as an Alternative for the Determination of Phthalic Monoesters in Urine Samples
نویسندگان
چکیده
Phthalates are widely used in industry, but adverse effects on human health have been reported due to exposure these chemicals. In the body, they metabolized into phthalic monoesters, which monitor and assess risk. Urine is one of main biological samples used, its easy access collection, also being elimination pathway for phthalates. complex; therefore, sample preparation a critical step. Disposable pipette extraction (DPX) has not previously quantifying phthalates urine here presented as fast low consumption method. A fully optimized RP-DPX method was developed determination free monomethyl phthalate, monobutyl monobenzyl monoethylhexyl phthalate from samples. Analytical parameters merit were obtained. The values R2 ≥0.9832, LOD LOQ varied 3.0 7.6 μg L−1 10 25 L−1, respectively. Intraday (n = 3) interday 9) precision ≤13.6 15.6%. accuracy, relative recovery, range 83 120%. robust after performing Youden test. Compared other methods, this work stands out short time consumption.
منابع مشابه
Simultaneous Determination of Carbazoles in Water Samples by Cloud Point Extraction Coupled to HPLC
Cloud point extraction (CPE) as a rapid, simple and efficient method coupled with high performance liquid chromatography (HPLC) was used for sample preparation and subsequent determination of carbazole, trinitrocarbazole (TrNC) and tetra nitro carbazole (TNC) in water samples. Some effective parameters on extraction, such as volume of Triton X-100, extraction time, extraction temperature, ionic...
متن کاملhydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction
hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...
simultaneous determination of carbazoles in water samples by cloud point extraction coupled to hplc
متن کامل
New Automated Screening System for the Determination of Basic Compounds in Urine by On-Line Extraction-HPLC- DAD
A new automated, qualitative screening HPLC method for the identification of basic compounds in urine has been established. A 1-ml volume of urine was automatedly extracted online and separated on two coupled strong cation-exchange columns under isocratic conditions. The use of the photodiode-array detector (DAD, λ=190-370 nm) gave access to a library of more than 2600 toxicologically relevant ...
متن کاملapplication and construction of carbon paste modified electrodes developed for determination of metal ions in some real samples
ساخت الکترودهاِی اصلاح شده ِیکِی از چالشهاِی همِیشگِی در دانش شیمِی بوِیژه شیمِی تجزیه مِی باشد ،که با در نظر گرفتن سادگِی ساخت، کاربردی بودن و ارزان بودن روش مِی توان به باارزش بودن چنِین سنسورهاِی پِی برد.آنچه که در ادامه آورده شده به ساخت و کاربرد الکترودهاِی اصلاح شده با استفاده از نانو ذرات در اندازه گِیرِی ولتامترِی آهن وکادمِیم اشاره دارد. کار اول اختصاص دارد به ساخت الکترود خمِیر کربن اصلاح شده با لِیگاند داِ...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Separations
سال: 2022
ISSN: ['2297-8739']
DOI: https://doi.org/10.3390/separations9100294